With only 60 seconds before nukes reduce the space station to floating particles in the vacuum of space, frantically grab whatever supplies and crew you can before getting out of there. You never know when that sock puppet will come in handy.
Space funerals are inconvenient, so try to avoid dying where possible. Use your limited supplies and (hopefully not limited) wits to make difficult choices and ensure your survival, even though the odds are definitely stacked against you.
Duct tape fixes all problems, but how do you fix (or at least craft) duct tape? Chart expeditions to find resources, craft survival essentials and explore strange new worlds in a procedural, very-much-permadeath adventure.
As captain, it's your duty to keep the crew happy - they're less likely to kill you that way. Manage relationships as you watch them grow closer and hopefully not throw each other out the airlock.