The Looney Tunes platformer Daffy Duck in Hollywood received a unique version for Sega's 8-bit systems. While similar in story, concept and themes to the Mega Drive version, the 8-bit version has unique level designs and also several differences in gameplay. Players control Daffy Duck, who is hired to reacquire Yosemite Sam's Golden Cartoon Movie Awards, stolen by the nefarious Doctor Duck Brain. Daffy has to make his way through six different worlds of three levels each. Each world is based on a movie genre including western, horror, adventure, sci-fi and more. At the beginning of the game, the six levels of the first two worlds can be selected in any order. Completing all six unlocks the levels of the next two worlds.