The Last Tempest

Mechanically it feels similar to Snake, Rattle 'n Roll on the NES and Mega Drive: you control a serpentine head with a multi-jointed tail that follows your movement. You also need to make precise jumps over voids in an isometric environment (stages loop around seamlessly when you reach the edge). The main difference is that instead of eating Nibbley Pibbleys to grow larger, you simply need to kill every enemy by ramming them (also some bosses). What makes The Last Tempest especially interesting is its scathing portrayal of religion; all of the enemies are based on Biblical characters and stages are littered with religious iconography, including bleeding crucifixes. Do not load this up near anyone offended by blasphemy. It's a bit too difficult, with strict time limits and tricky jumps, but there's infinite continues and honestly little else like it.