In the game, Rena is a cat who is the mascot of a blog named 'Nekopunch' and the CEO of a fictional company named Cat Queen, Inc. It is the player's objective to appease Rena in order to get accepted into working for Rena. Sukeban Shachou Rena's gameplay involves several minigames where the player takes control of a cat or in other minigames, humans. Minigame examples include playing the piano, avoiding other cats from jumping at you, taking money from a cat while it is not looking, and dancing using the Wii Remote to appease Rena.